Table 2 Multivariable logistic regression analysis for pathological upgrading of cervical biopsy from CIN3 to cancer after conical resection

Age (years)

0.92 (0.90, 0.95)

< 0.001

0.90 (0.86, 0.94)

< 0.001

Gravidity

0.95 (0.84, 1.07)

0.400

Parity

0.86 (0.68, 1.08)

0.201

Menopausal Status

Yes

0.58 (0.38, 0.88)

0.011

2.68 (1.38, 5.22)

0.004

No

ref

ref

TCT

HSIL

ref

ref

Non-HSIL

1.77 (1.07, 2.94)

0.027

1.80 (0.99, 3.29)

0.055

Unknown

2.34 (1.44, 3.80)

0.001

1.61 (0.91, 2.89)

0.098

High-risk HPV infection

HPV16/18 positive

ref

ref

Other high-risk types

0.45 (0.23, 0.90)

0.023

0.54 (0.25, 1.15)

0.111

Not checked

0.69 (0.42, 1.12)

0.135

0.80 (0.44, 1.43)

0.443

HPV negative

-

-

-

-

Involvement of glandular tissue

Yes

0.66 (0.41, 1.06)

0.084

No

ref

Clinical symptoms

Contact bleeding

4.81 (3.06, 7.54)

< 0.001

4.80 (2.91, 7.91)

< 0.001

Abnormal vaginal discharge

1.81 (0.88, 3.71)

0.108

1.41 (0.63, 3.15)

0.406

Asymptomatic, detected during routine examination

ref

ref

High-density lipoprotein

0.71 (0.37, 1.35)

0.298

Albumin

0.98 (0.94, 1.03)

0.464

Lymphocyte count

1.12 (0.87, 1.44)

0.389

Monocyte count

1.19 (0.52, 2.74)

0.680

Neutrophil count

1.16 (1.04, 1.29)

0.008

1.09 (0.96, 1.23)

0.189

Eosinophil count

1.77 (0.35, 8.90)

0.487

Red blood cell count

1.26 (0.79, 2.02)

0.332

Hemoglobin

1.00 (0.98, 1.01)

0.562

Hematocrit

0.96 (0.91, 1.02)

0.210

Red cell distribution width

1.02 (0.98, 1.05)

0.370

Platelet count

1.00 (1.00, 1.01)

0.030

1.00 (1.00, 1.00)

0.714

Mean platelet volume

0.83 (0.71, 0.96)

0.014

0.83 (0.69, 0.99)

0.038

Fibrinogen

1.01 (0.83, 1.22)

0.928