Fig. 4

Heatmap comparing RNA expression between WT and KO of EPPK1 in A549 cells. A Heatmap demonstrates that oncogenes were downregulated after silencing EPPK1 in A549 cells. The color scale relates to RNA expression levels: red, high; white, normal; blue, low expression. B RNA seq results demonstrate that the expression of tumor suppressor genes is upregulated after silencing EPPK1 in A549 cells. C RNA seq results demonstrate that angiogenesis genes were downregulated after silencing EPPK1 in A549 cells. D RNA seq results demonstrate that the expression of anti-apoptosis genes was downregulated after silencing EPPK1 in A549 cells. E RNA seq results demonstrate that the expression of anti-cell growth genes was upregulated after silencing EPPK1 in A549 cells