Fig. 1

Screening and identification of differentially co-expressed genes. A Different colors represent the number of up-regulated genes in different datasets, and the middle intersection represents the number of co-expressed genes in the three GSE (GSE73731, GSE89563, GSE150404) datasets. B PSAT1 expression. C PRAME expression. D KDELR3 expression. Red dots represent the number of cases in the late-stage ccRCC group, blue dots represent the number of cases in the early-stage ccRCC group. Horizontal line in the middle of the box: represents the median. Top and bottom lines of the box: represent the upper and lower quartiles. The bin size represents the quartile spacing. G1: late-stage group; G2: early-stage group. ****p < 0.0001. E The heatmap illustrates the expression levels of potential 3 genes. Each row represents the expression level of each gene in different samples, and each column represents the expression level of all genes in each sample