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Table 2 Characteristics for immunotherapy cohorts

From: A radiomics signature derived from CT imaging to predict MSI status and immunotherapy outcomes in gastric cancer: a multi-cohort study

 

ZZU cohort (n = 184)

SDU cohort (n = 43)

Characteristic

CR + PR

SD + PD

p value

CR + PR

SD + PD

p value

Age (years)

  

0.874

  

 > 0.999

 < 65

39 (60.94)

75 (62.50)

 

18 (100)

25 (100)

 

≥ 65

25 (39.06)

45 (37.50)

 

0 (0)

0 (0)

 

Sex

  

0.308

  

0.701

 Male

49 (76.56)

83 (69.17)

 

14 (77.78)

21 (84.00)

 

 Female

15 (23.44)

37 (30.83)

 

4 (22.22)

4 (16.00)

 

Location

  

0.189

  

0.624

 Cardia

39 (60.94)

54 (45.00)

 

6 (33.33)

12 (48.00)

 

 Body

12 (18.75)

33 (27.50)

 

5 (27.78)

7 (28.00)

 

 Antrum

13 (20.31)

31 (25.83)

 

6 (33.33)

4 (16.00)

 

 Whole

0 (0.00)

2 (1.67)

 

1 (5.6)

2 (8.00)

 

Clinical T stage

  

0.366

  

> 0.999

 T3

18 (28.12)

26 (21.67)

 

0 (0)

0 (0)

 

 T4

46 (71.88)

94 (78.33)

 

18 (100)

25 (100)

 

Clinical N stage

  

0.457

  

0.253

 N-

16 (25.00)

24 (20.00)

 

0 (0)

3 (12.00)

 

 N+

48 (75.00)

96 (80.00)

 

18 (100)

22 (88.00)

 

CA 72−4 level

  

0.872

  

> 0.999

 Normal

21 (32.81)

41 (34.17)

 

4 (22.22)

5 (20.00)

 

 Abnormal

43 (67.19)

79 (65.83)

 

14 (77.78)

20 (80.00)

 

CA 19−9 level

  

0.498

  

0.765

 Normal

16 (25.00)

36 (30.00)

 

7 (38.89)

11 (44.00)

 

 Abnormal

48 (75.00)

84 (70.00)

 

11 (61.11)

14 (56.00)

 

CEA level

  

0.640

  

0.099

 Normal

28 (43.75)

48 (40.00)

 

15 (83.33)

14 (56.00)

 

 Abnormal

36 (56.25)

72 (60.00)

 

3 (16.67)

11 (44.00)

 

Radiomics score *

1.06 (0.69, 1.35)

1.47 (1.18, 1.87)

< 0.001

1.02 (0.03, 1.34)

1.42 (1.00, 1.93)

0.012

  1. Note: Except where indicated, data are number (%) of patients. MSI-H = microsatellite instability-high, MSS = microsatellite stability, CA 72 − 4 = carbohydrate antigen 72 − 4, CA 19 − 9 = carbohydrate antigen 19 − 9, CEA = carcinoembryonic antigen, PFS = Progression-free survival, OS = Overall survival
  2. * Data in parentheses are interquartile range