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Table 1 Target volume goals for standard and experimental arms

From: SABR-Dual: a phase II/III trial of two-fraction versus five-fraction stereotactic radiotherapy for localized low- and favorable intermediate-risk prostate cancer

Structure

Parameter (Gy)

Per protocol

Variation acceptable

Notes

PTV_4000

V40

≥ 95%

 

Arm 1

V39.6

≥ 97%

≥ 95%

D0.03 cc*

< 107%

< 108%

CTV_4000

V39.6

≥ 100%

≥ 99%

PTV_3500

V35

≥ 95%

 

CTV_3500

V33.95

≥ 97%

≥ 95%

PTV_2700

V27

≥ 95%

 

Arm 2

 

V26.73

≥ 97%

≥ 95%

 

D0.03 cc*

< 107%

< 108%

CTV_2700

V26.73

≥ 100%

≥ 99%

PTV_2300

V23

≥ 95%

 

CTV_2300

V22.31

≥ 97%

≥ 95%

  1. *When a simultaneous integrated boost is prescribed, maximum allowed dose to the primary PTV (either PTV_4000 or PTV_2700) will be limited to 102% of the boost dose– D0.03cc < 45.9 Gy or D0.03cc < 30.6 Gy. There is no specific minimum required SIB coverage for GTV, when present, but minimal coverage of 95% of volume covered by 95% of dose is recommended.