Table 5 Subgroup analysis stratified by distance from key structures

≤ 10 mm from hilum/pleura/interlobar fissure

Demographics and baseline

Sex, no. (%)

Male

Female

N = 54

34 (63%)

20 (37%)

N = 18

10 (55.6%)

8 (44.4%)

0.712

Mean age (years)

Age (years), no. (%)

<65

≥65

Primary tumor location, no. (%)

Right colon

Left colon

Rectum

Maximum tumor diameter (cm, mean ± SD)

Tumor size, no. (%)

≤3 cm

>3 cm

Tumor number, no. (%)

1

2

3

Distribution of lung metastasis, no. (%)

Unilateral

Bilateral

65.9 ± 6.7

32 (59.3%)

22 (40.7%)

24 (44.4%)

16 (29.6%)

14 (26)

3.9 ± 1.3

30 (51.4%)

24 (48.6%)

12 (22.2%)

26 (48.2%)

16 (29.6%)

34 (63%)

20 (37%)

61.5 ± 8.2

12 (66.7%)

6 (33.3%)

6 (33.3%)

6 (33.3%)

6 (33.3%)

2.8 ± 0.7

12 (66.7%)

6 (33.3%)

8 (44.5%)

6 (33.3%)

4 (22.2%)

10 (55.6%)

8 (44.4%)

0.263

> 0.99

0.892

0.067

0.439

0.612

0.712

Location of lung metastasis, no. (%)

Adjacent to the hilum

Adjacent to the pleura/interlobar fissure

Lung metastasis, no. (%)

Metachronous

Synchronous

CEA (ng/ml), no. (%)

<10

≥10

Complication, no. (%).

Pneumothorax

Bronchopleural fistula

Pleural effusion

Hydropneumothorax

Survival

LTPFS at 1 year, no. (%)

Yes

No

LTPFS at 3 years, no. (%)

Yes

No

Median LTPFS (months)

OS at 1 year, no. (%)

Yes

No

28 (51.9%)

26 (48.1%)

38 (70.4%)

16 (29.6%)

18 (33.3%)

36 (66.7%)

16 (29.6%)

10 (18.5%)

0

4 (7.4%)

2 (3.7%)

30 (55.6%)

24 (44.4%)

20 (37%)

34 (63%)

17.4 (95% CI: 8.9–23.1)

40 (74.1%)

14 (25.9%)

6 (33.3%)

12 (66.7%)

8 (44.4%)

10 (55.6%)

8 (44.4%)

10 (55.6%)

16 (88.9%)

8 (44.4%)

6 (33.3%)

0

2 (11.1%)

8 (44.4%)

10 (55.6%)

6 (33.3%)

12 (66.7%)

16.8 (95% CI: 8.4–22.7)

12 (66.7%)

9 (33.3%)

0.451

0.235

0.693

0.005

0.706

> 0.99

0.793

0.686

OS at 3 years, no. (%)

Yes

No

Median OS (months)

> 10 mm from hilum/pleura/interlobar fissure

Demographics and baseline

Sex, no. (%)

Female

Male

Mean age (years)

Age (years), no. (%)

< 65

≥ 65

Primary tumor location, no. (%)

Right colon

Left colon

Rectum

Maximum tumor diameter (cm, mean ± SD)

Tumor number, no. (%)

1

2

3

Distribution of lung metastasis, no. (%)

Unilateral

Bilateral

Lung metastasis, no. (%)

Metachronous

Synchronous

CEA (ng/ml), no. (%)

< 10

≥ 10

Complication, no. (%)

Pneumothorax

Pleural effusion

Hydropneumothorax

Fever

Survival

LTPFS at 1 year, no. (%)

Yes

No

LTPFS at 3 years, no. (%)

Yes

No

Median LTPFS (months)

OS at 1 year, no. (%)

Yes

No

OS at 3 years, no. (%)

Yes

No

Median OS (months)

26 (48.1%)

28 (51.9%)

22.5 (95% CI: 15.6–32.1)

N = 20

8 (40%)

12 (60%)

61.3 ± 6.5

14 (70%)

6 (30%)

6 (30%)

4 (20%)

10 (50%)

7.1 ± 1.5

6 (30%)

8 (40%)

6 (30%)

10 (50%)

10 (50%)

18 (90%)

2 (10%)

10 (50%)

10 (50%)

18 (90%)

10 (50%)

2 (10%)

6 (30%)

0

10 (50%)

10 (50%)

10 (50%)

10 (50%)

16.9 (95% CI: 7.8–23.6)

16 (80%)

4 (20%)

10 (50%)

10 (50%)

19.3 (95% CI: 14.9–34.6)

8 (44.4%)

10 (55.6%)

20.8 (95% CI: 16.1–33.6)

N = 30

16 (53.3%)

14 (46.7%)

56.5 ± 4.8

16 (53.3%)

14 (46.7%)

12 (40%)

10 (33.3%)

8 (26.7%)

2.1 ± 0.5

10 (33.3%)

8 (26.7%)

12 (40%)

14 (46.7%)

16 (53.3%)

26 (86.7%)

4 (13.3%)

16 (53.3%)

14 (46.7%)

16 (53.3%)

8 (26.7%)

2 (6.7%)

0

6 (20%)

20 (66.7%)

10 (33.3%)

14 (46.7%)

16 (53.3%)

20.1 (95% CI: 8.6–23.8)

12 (40%)

18 (60%)

16 (53.3%)

14 (46.7%)

25.3 (95% CI: 14.7–38.3)

> 0.99

0.65

0.688

0.153

0.678

0.596

0.036

0.879

> 0.99

> 0.99

> 0.99

0.088

0.442

> 0.99

0.671

0.099

> 0.99

0.787