Table 4 DDR PVs identified in ancient humans. Number of DDR PVs identified in ancient humans

ATM

147

RAD51

5

BRCA2

122

XPA

5

BRCA1

116

ATR

4

FANCA

67

DCLRE1C

4

MLH1

66

ERCC4

4

MSH2

59

LIG4

4

TP53

50

NHEJ1

4

PALB2

48

RAD54L

4

MSH6

46

RNASEH2C

4

RAD50

38

SLX4

4

MUTYH

33

SSBP1

4

BRIP1

33

XRCC4

4

PMS2

32

ERCC1

3

ERCC6

30

FAN1

3

BARD1

28

RNASEH1

3

CHEK2

28

TELO2

3

NBN

24

FANCF

2

BLM

21

GTF2H5

2

FANCC

17

LIG1

2

RAD51D

16

LIG3

2

MSH3

15

MCM2

2

FANCD2

12

RBBP8

2

RAD51C

12

XRCC2

2

XPC

12

MCM7

2

ERCC2

11

RAD51B

1

FANCI

11

DDB2

1

FANCG

10

DNA2

1

MRE11

10

FANCL

1

ERCC3

9

MCM5

1

ERCC8

8

POLD1

1

RNASEH2B

8

TOP3A

1

ERCC5

7

UBE2T

1

RNASEH2A

7

UIMC1

1

FANCE

6

UNG

1

FANCM

6

XRCC1

1

NTHL1

6

MCM4

1

POLH

5