Fig. 5

Relationship between evolution selection and DDR genes. It shows the type of evolution selection in the 73 PV-containing DDR genes. The PAML program was used for the test in 21 vertebrate species. A Summary of the DDR genes under positive, negative, and neutral selection. It shows that most of DDR genes were under negative selection. The number in parentheses refers to the PVs identified in ancient humans as list in Table 4. B TP53 under positive selection. It shows that TP53 is under positive selection in all 21 species tested but with different dN/dS ratios in different species. C Number of PV per DDR gene in each type of selection group. It shows that the positive selection group had the highest number, the neutral group had the intermediate number, and the negative group had the lowest number of PVs per gene