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Fig. 3 | BMC Cancer

Fig. 3

From: Pathogenic variants in human DNA damage repair genes mostly arose in recent human history

Fig. 3

Timing of DDR PVs of ancient humans shared with modern humans. A Timing distribution of 67 recurrent PVs in 33 DDR genes shared between modern and ancient humans within 10,000 years BP (a few longer than 10,000 years BP were not included due to space limitation). The larger red dot in each PV line represents the earliest identified PV carrier, and the smaller black dot (s) in the same line correspond to the later carriers of the same PV. The line to the left of the larger red dot indicates the presence of PV-free sample(s) older than the first PV carrier, showing that older ancient sample(s) were present for all first identified recurrent PVs carriers, Supplementary Table 7), the line to the right of the last smaller black dot denotes the presence of PV-free sample(s) younger than the last PV carriers. B Different PVs in 73 DDR genes shared between modern and ancient humans within the last 10,000 years (a few longer than 10,000 years BP were not included due to space limitation). Each dot represents a single PV. The larger red dot in each DDR gene line represents the earliest PV identified in the gene, and the smaller black dot (s) in the same line represents different PVs detected later in the same DDR gene. Most of the PVs were present in the carriers dated within the last 5000 year BP. It shows that older ancient samples were present for all firstly identified PVs carriers (Supplementary Table 7)

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