Fig. 2
From: Pathogenic variants in human DNA damage repair genes mostly arose in recent human history
Phylogenetic analysis of human DDR PVs in 100 vertebrate species. The 7432 single nucleotide PVs in 87 DDR genes from ClinVar database were searched in 100 vertebrate species with 8 clades of Primate, Euarchontoglires, Laurasiatheria, Afrotheria, Mammalia, Aves, Sarcopterygii and Fish. The results showed that the majority of human DDR PVs were not shared, whereas 1497 (20.14%) were shared with non-human vertebrate species mostly distal to human such as the species within Aves and Sarcopterygii, and rarely with species within Primate. Y-axis: species; X-axis: PVs in DDR genes. Red: human PVs shared with other species