Table 3 Summary of best overall response per RECIST 1.1 criteria (full analysis set, phase 1b/2)
| Â | Doublet Arms | Triplet Arms | ||||
|---|---|---|---|---|---|---|
|  | Arm 1A (n = 10) | Arm 2A (n = 27) | Pooled (n = 37) | Arm 1B (n = 11) | Arm (2B n = 27) | Pooled (n = 38) |
Best overall response, n (%)a, b | ||||||
 CR | 0 | 0 | 0 | 0 | 0 | 0 |
 PR | 0 | 0 | 0 | 0 | 2 (7.4) | 2 (5.3) |
 SD | 6 (60.0) | 11 (40.7) | 17 (45.9) | 4 (36.4) | 13 (48.1) | 17 (44.7) |
 PD | 4 (40.0) | 15 (55.6) | 19 (51.4) | 3 (27.3) | 10 (37.0) | 13 (34.2) |
 Not evaluable | 0 | 1 (3.7) | 1 (2.7) | 4 (36.4) | 2 (7.4) | 6 (15.8) |
Overall response rate (CR + PR), n (%)b [90% CI] [95% CI] | 0 | 0 | 0 | 0 | 2 (7.4) [1.3, 21.5] [0.9, 24.3] | 2 (5.3) [0.9, 15.7] [0.6, 17.7] |
Disease control rate (CR + PR + SD), n (%) [95% CI] | 6 (60.0) [26.2, 87.8] | 11 (40.7) [22.4, 61.2] | 17 (45.9) [29.5, 63.1] | 4 (36.4) [10.9, 69.2] | 15 (55.6) [35.3, 74.5] | 19 (50.0) [33.4, 66.6] |