Fig. 3
From: Targeting PCSK9 to upregulate MHC-II on the surface of tumor cells in tumor immunotherapy
Regulatory effects of PCSK9 expression on tumor immune cells infiltration and MHC expression. (A) Heat map of correlation between PCSK9 expression and infiltration of B cell, CD8 + T cell, CD4 + T cell, macrophage, neutrophil, and DC. (B) Heat map of correlation between PCSK9 expression and infiltration of M2 macrophage, myeloid-derived suppressor cell, regulatory T cell, and cancer-associated fibroblast. (C) Heat map of correlation between PCSK9 expression and MHC molecules expression in pan-cancer. (D) Heat map of correlation between PCSK9 expression and MHC molecules expression in STAD. (E) Heat map of correlation between PCSK9 expression and MHC molecules expression in SKCM. *P < 0.05; **P < 0.01; ***P < 0.001)