Fig. 4

Correlations between UGT2B17 expression and regulatory transcription factors (TFs) in the ICGC CLL cohort and LL100 preclinical leukemic cells. (A) Correlation of UGT2B17 expression with the expression of regulatory TF in CLL cases of the ICGC cohort (n = 294) and in the lymphoma and leukemic cell models of the LL100 collection. (B) Correlation of UGT2B17 expression with TF activity according to DoRothEA regulons in the CLL/ICGC cohort and the LL100 collection. (C) Correlation of UGT2B17 expression with the expression of NF-κB, STAT3 and IRFs target genes relevant to CLL in the ICGC cohort. (D) The elevated expression of IRF2, IRF5 and IRF6 are associated with poor overall survival in CLL patients of the ICGC cohort, dichotomized on the median expression of each TF. LRT: log-rank test. *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001; t, trend