Table 4 miRNAs regulated by ATRA in lung cancer cell lines
Study (reference and country) | Cell type | ATRA treatment | miRNAs upregulated | miRNAs downregulated |
|---|---|---|---|---|
Zhu et al. (2015) [3] China | A549 and H1299 | 10 and 100 μmol/L for 24 h (A549); and 100 μmol/L for 72 h (H1299) | 8; miR-594, miR-519b, miR-504, miR-512-3p, miR-363, miR-517a, miR-518a and miR95; most significant: 512-3p | 5; mir-223, miR-196a, miR-369-3p, miR-146a and miR-142-3pa |
Chu et al. (2016) [4] China | H1299 and A549 | 10 and 100 μmol/L for 72 h | miR-512-5p | – |