Fig. 6

DZNep reduces viability of chondrosarcomas embedded in alginate and engrafted in mice. a Chondrosarcomas cultured in monolayer or embedded in alginate for at least 2 weeks were treated with DZNep (1 μM) for 14 days. Then, viability was evaluated and compared to untreated cells. Values represent means ± SEM of 3 independent experiments. **: p-value <0.01; ***: p-value <0,001. b Tumors were implanted as previously (Fig. 4b) and treated with DZNep (i.p., 2 mg/kg, three times per week). Tumors were measured by a caliper and tumoral volume is showed. *: p-value <0.05