Fig. 5From: Identification of an easy to use 3D culture model to investigate invasion and anticancer drug response in chondrosarcomasCisplatin does not reduce the viability of chondrosarcomas embedded in alginate or engrafted in nude mice. a Chondrosarcomas cultured in monolayer or embedded in alginate for at least 2 weeks were treated with cisplatin (10 μM) for 3 days. Then, viability was evaluated and compared to untreated cells. Values represent means ± SEM of 3 independent experiments. *: p-value <0.05; **: p-value <0.01. b Nude mice were injected with 100 μl of matrigel containing 106 chondrosarcoma cells. When the tumors were palpable, mice were treated for 25 days with cisplatin (i.p., 2 mg/kg, three times per week). Tumors were measured by a caliper and tumoral volume calculated by the following eq. (L x w2) /2 (with L corresponding to length and w to width)Back to article page