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Fig. 3 | BMC Cancer

Fig. 3

From: JMJD2A promotes the Warburg effect and nasopharyngeal carcinoma progression by transactivating LDHA expression

Fig. 3

Transcriptional activation of LDHA expression by JMJD2A in NPC cells. a-b Chip assays revealed that JMJD2A knockdown decreased the binding of JMJD2A to the LDHA promoter in CNE2 (A) and 5-8F (B) cell lines. c-d JMJD2A overexpression increased JMJD2A binding to the LDHA promoter in CNE1 (C) and HONE1 (D) cells. e-h Luciferase reporter assay were performed to detect the effect of JMJD2A on LDHA transcription. Silencing of JMJD2A decreased LDHA promoter activity in CNE2 (E) and 5-8F (F) cell lines, whereas JMJD2A overexpression elevated the LDHA promoter activity in CNE1 (G) and HONE1 (H) cell lines. *P < 0.05

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BMC Cancer

ISSN: 1471-2407

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