Fig. 3

MMP inhibition reduces angiogenic protein levels. Y79 and Weri-1 cells were cultured in the presence or absence of the MMPI overnight. Next day, we collected cell lysates (a-b) and supernatants to investigate protein levels by ELISA. a shows VEGF protein levels; b shows Ang-2 protein levels and c, shows levels of TGF-β1, an immunomodulator. In all secretion analyses bar graphs indicate results ±SD; n = 3; *p < 0.05, **p < 0.005, #p = 0.05