Fig. 4

Knockdown of RCE1 increases the invasion capacity of CRC cells. a Real-time quantitative PCR analysis detected RCE1 expression in HCT116 and SW480 cells that were infected with an shRNA-lentivirus targeting RCE1. b Infection with lentivirus targeting RCE1 significantly decreased RCE1 expression and levels of phosphorylated p38. c and d Infection with lentivirus against RCE1 significantly increased the invasion capacity of HCT116 and SW480 cells, *p < 0.01. e Representative samples of RCE1 and p-p38 staining in the serial sections from the same tumor tissues. f The scatter plot shows that the RCE1 expression is positively correlated with p-p38 expression