CUL4A overexpression as an independent adverse prognosticator in intrahepatic cholangiocarcinoma

BMC Cancer

Table 1 Results of univariate long-rank analysis of prognostic factors for overall survival and disease-free survival

Parameters	No. of patients	Overall survival		Disease-free survival
Parameters	No. of patients	No. of events	P value	No. of events	P value
Age, years
≤ 60	54	31	0.452	36	0.757
> 60	51	33		34
Gender
Male	58	39	0.392	38	0.538
Female	47	25		32
Gross pattern
MF	62	33	0.004^a	40	0.142
MF + PI	42	31		29
Tumor N
Solitary	87	50	0.021^a	54	0.003^a
Multiple	16	12		15
Tumor size
≤ 5 cm	52	32	0.084	27	< 0.001^a
> 5 cm	46	29		38
Margin
≤ 1 cm	66	45	0.025^a	49	0.011^a
> 1 cm	28	15		17
Necrosis
≤ 10%	77	45	0.134	49	0.104
> 10%	28	19		21
VI
No	64	37	0.122	35	0.001^a
Yes	41	27		35
NI
No	67	35	< 0.001^a	39	0.003^a
Yes	38	29		31
H grade
I	29	19	0.776	17	0.398
II + III	76	45		53
pT
T1	34	16	0.008^a	18	0.005^a
T2 - T4	67	47		50
LN
No	40	23	0.198	26	0.353
Yes	12	8		9
Stage
I	30	14	0.006^a	16	0.009^a
II + III + IV	71	49		52
CUL4A
< 50	71	42	0.245	42	0.011^a
≥ 50	34	22		28

M mass-forming type, PI periductal infiltrating type, N number, VI vascular invasion, NI neural invasion, H histology, pT tumor stage, LN lymph node metastasis
^aStatistically significant

ISSN: 1471-2407