Case No. | Stage |
VHL LOHa
| Gradeb
| pVHLc
|
---|
Normal | Dysplasia | Tumor (differentiation) |
---|
Well | Moderate | Poor |
---|
1 | II | P | 1 | | A | ++ | ++ | |
2 | II | P | 1 | | | ++ | | |
3 | II | P | 1 | | | ++ | | |
4 | II | P | 2 | | | ++ | ++ | |
5 | II | N | 1 | | A | ++ | | |
6 | IV | N | 1 | | | ++ | | |
7 | IV | N | 1 | ++ | | ++ | | |
8 | I | N | 1 | ++ | B | ++ | | |
9 | II | ni | 1 | | | ++ | | |
10 | III | ni | 1 | ++ | C | ++ | | + |
11 | I | ni | 1 | | A | ++ | | |
12 | I | ni | 1 | ++ | | ++ | | |
13 | II | ni | 1 | | A | ++ | ++ | |
14 | I | ni | 1 | | | ++ | | |
15 | II | ni | 1 | | A | ++ | | |
16 | II | ni | 2 | | | ++ | ++ | + |
17 | IV | ni | 2 | | A | | ++ | |
18 | III | ni | 2 | | A | | ++ | |
19 | III | ni | 3 | | | | | + |
Total | | | | 4 | 9 | 16 | 6 | 3 |
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a LOH, loss of heterozygosity, determined by single nucleotide polymorphism of the VHL gene (10). P, positive; N, negative; ni, non-informative
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b Grade 1, well-differentiated; grade 2, moderately differentiated; grade 3, poorly differentiated
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c All FFPE specimens from 19 cases were examined for histological features and immunohistochemistry of pVHL. All specimens examined were positive for pVHL: ++, strongly positive; +, weakly positive; patterns A, B and C are classifications of dysplasia determined by immunohistochemistry of pVHL together with CK13 and CK17, as shown in Fig. 2b