Table 4 Univariate and multivariate analyses of overall survival for 109 patients who received chemotherapy for metastatic appendiceal adenocarcinoma
Variable | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
HR | (95% CI | P value | HR | (95% CI | P-value | |
Male gender | 1.43 | (0.93–2.21) | 0.10 | 1.72 | (1.05–2.84) | 0.03 |
Presence of signet ring cells | 1.19 | (0.76–1.85) | 0.27 | |||
Lymph node metastasis | 0.77 | (0.46–1.29) | 0.32 | |||
Peritoneal only metastases | 1.19 | (0.77–1.85) | 0.22 | 1.29 | (0.76–2.19) | 0.35 |
Extraperitoneal only metastases | 2.07 | (0.91–4.73) | 0.08 | 2.64 | (1.09–6.38) | 0.03 |
Oxaliplatin or Irinotecan-based therapy vs. Fluoropyrimidine alone | 2.55 | (1.6–6.48) | 0.05 | 2.08 | (0.80–5.39) | 0.13 |
Age > or = 50 yrs. vs. < 50 yrs. | 0.99 | (0.64–1.52) | 0.95 | |||
White vs. Non-White | 0.71 | (0.38–1.31) | 0.27 | |||
Poorly differentiated histology | 1.01 | (0.65–1.55) | 0.97 | |||
Cytoreductive surgery: Yes vs. No | 0.74 | (0.45–1.23) | 0.25 | |||