Fig. 3From: Paraneoplastic acral vascular syndrome in a patient with metastatic melanoma under immune checkpoint blockadeTwenty days after the second application of ipilimumab/nivolumab combination therapy the violaceous erythema was increased (a). The patient suffered from paraesthesia and strong pain. Six weeks later a severe gangrene was observed on digitus 3 of the left hand (b)Back to article page