SNP | Nearest gene | Effect allele/ Other allele | Favorable Energy Balance Group | Unfavorable Energy Balance Group | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Direct effect | Indirect effect | Total effect | Direct effect | Indirect effect | Total effect | |||||||||
CRC risk in relation to SNP through pathways other than HOMA-IR | CRC risk in relation to SNP through HOMA-IR | CRC risk in relation to SNP | CRC risk in relation to SNP through pathways other than HOMA-IR | CRC risk in relation to SNP through HOMA-IR | CRC risk in relation to SNP | |||||||||
HRa | 95% CI | Effect sizea | 95% CI | HRa | 95% CI | HRa | 95% CI | Effect sizea | 95% CI | HRa | 95% CI | |||
BMIb | ||||||||||||||
 rs2191349 | DGKB/TMEM195 | G/T | 1.04 | (0.84–1.28) | <0.001 | (−0.004–0.004) | 1.07 | (0.90–1.28) | 1.45 | (1.03–2.03) | <0.001 | (−0.003–0.003) | 1.17 | (0.90–1.52) |
 rs4607517 | GCK | G/A | 0.79 | (0.61–1.03) | <0.001 | (−0.01–0.01) | 0.80 | (0.64–1.00) | 1.04 | (0.66–1.62) | <0.001 | (−0.004–0.003) | 1.06 | (0.75–1.51) |
 rs174550 | FADS1 | T/C | 1.16 | (0.93–1.45) | <0.001 | (−0.001–0.001) | 1.05 | (0.87–1.27) | 1.40 | (0.96–2.04) | −0.01 | (−0.02–0.01) | 1.37 | (1.02–1.83) |
 rs11605924 | CRY2 | C/A | 0.87 | (0.71–1.07) | <0.001 | (−0.01–0.01) | 0.82 | (0.69–0.98) | 1.32 | (0.93–1.87) | <0.001 | (−0.003–0.003) | 1.07 | (0.82–1.39) |
Waistc | ||||||||||||||
 rs2191349 | DGKB/TMEM195 | G/T | 0.97 | (0.76–1.23) | 0.002 | (−0.01–0.01) | 1.00 | (0.81–1.23) | 1.37 | (1.05–1.79) | −0.002 | (−0.004–0.01) | 1.20 | (0.97–1.48) |
 rs174550 | FADS1 | T/C | 1.22 | (0.94–1.58) | −0.002 | (−0.01–0.01) | 1.03 | (0.83–1.28) | 1.24 | (0.93–1.65) | −0.01 | (−0.02–0.002) | 1.25 | (1.00–1.57) |
 rs11605924 | CRY2 | C/A | 0.84 | (0.67–1.06) | <0.001 | (−0.01–0.01) | 0.81 | (0.66–0.99) | 1.17 | (0.90–1.54) | <0.001 | (−0.01–0.01) | 0.97 | (0.79–1.20) |
Waist/hip Ratiod | ||||||||||||||
 rs2191349 | DGKB/TMEM195 | G/T | 1.04 | (0.84–1.29) | 0.003 | (−0.01–0.004) | 1.03 | (0.86–1.23) | 1.38 | (1.00–1.89) | <0.001 | (−0.01–0.01) | 1.24 | (0.97–1.59) |
 rs10885122 | ADRA2A | G/T | 0.78 | (0.58–1.05) | <0.001 | (−0.01–0.01) | 0.84 | (0.64–1.08) | 1.31 | (0.77–2.20) | <0.001 | (−0.01–0.01) | 1.58 | (1.01–2.48) |
 rs174550 | FADS1 | T/C | 1.15 | (0.92–1.45) | 0.002 | (−0.004–0.01) | 1.08 | (0.89–1.30) | 1.43 | (1.01–2.03) | −0.008 | (−0.02–0.004) | 1.27 | (0.97–1.66) |
Physical activity levele | ||||||||||||||
 rs4607517 | GCK | G/A | 0.73 | (0.52–1.01) | <0.001 | (−0.003–0.003) | 0.72 | (0.55–0.95) | 0.95 | (0.69–1.31) | −0.001 | (−0.01–0.004) | 0.99 | (0.76–1.28) |
Dietary fat intakef | ||||||||||||||
 rs4607517 | GCK | G/A | 0.92 | (0.72–1.18) | <0.001 | (−0.01–0.004) | 0.94 | (0.76–1.17) | 0.58 | (0.33–1.03) | −0.001 | (−0.01–0.001) | 0.66 | (0.43–1.00) |
 rs11558471 | SLC30A8 | A/G | 1.08 | (0.88–1.33) | <0.001 | (−0.01–0.01) | 0.95 | (0.80–1.12) | 1.64 | (0.94–2.85) | −0.003 | (−0.01–0.01) | 1.60 | (1.07–2.40) |