Genome-wide DNA methylation measurements in prostate tissues uncovers novel prostate cancer diagnostic biomarkers and transcription factor binding patterns

Table 2 Genomic regions of differentially methylated CpGs

Genomic location	Sig. CpGs more methylated in tumor	Sig. CpGs less methylated in tumor	Fisher’s exact p-value
A. Island versus non-island
CG Island	93,536	35,639	3.44E-154
Non-CG Island	58,787	38,273
B. Regulatory region versus gene body (All significant CpGs)
Regulatory Region	55,029	23,056	0.49
Gene Body	46,502	19,858
C. Regulatory Region Versus Gene Body (Top 10,000 most significant CpGs)
Regulatory Region	3165	776	1.50E-02
Gene Body	1902	700

Regulatory Region = promoter, first exon, first intron
Gene Body = other exon, other intron, 3′ proximal
CG Island = CG islands, CG shelves, and CG shores
A) Analysis of CpGs in islands versus non-islands. B) Analysis of CpGs in gene bodies versus gene regulatory regions for all significant CpGs. C) Analysis of CpGs in gene bodies versus gene regulatory regions for the top 10,000 most significant CpGs

ISSN: 1471-2407