Fig. 2

Overlap of top 10,000 most significant (LME p-value) DNA methylation sites in gene regulatory regions and higher methylation in prostate cancer tissues with ENCODE transcription factor binding sites highlights the role EZH2 plays in prostate cancer. a Barplot showing the relative percent of ENCODE transcription factor binding sites containing significant methylation changes. Dashed red lines represent the upper and lower 95% confidence intervals generated from enrichment values of randomly selected methylation sites. b Pie charts demonstrating the directionality of significant DNA methylation sites and gene expression levels within 1 kb of EZH2 binding sites