Table 1 Clinical data
Mutations and MSI | CIMP-H (true n = 32, clinical n = 26) | CIMP-L (true n = 13, clinical n = 10) | CIMP-N (true n = 47, clinical n = 37) | P value |
|---|---|---|---|---|
BRAF mutant | 14 (44%, 54%) | 0 (0%) | 3 (6%, 8%) | < 0.001 |
BRAF wildtype | 12 (38%, 46%) | 10 (77%, 100%) | 34 (72%, 92%) | Â |
KRAS mutant | 5 (16% 19%) | 5 (38%, 50%) | 6 (13%, 16%) | 0.039a |
KRAS wildtype | 21 (66%, 81%) | 5 (38%, 50%) | 31 (66%, 84%) | Â |
MSI | 9 (28%, 35%) | 1 (8%, 10%) | 6 (13%, 16%) | 0.133 |
MSS | 17 (53%, 65% | 9 (69%, 90%) | 31 (66%, 84%) | Â |
Colon location | Â | Â | Â | Â |
Proximal | 21 (66%, 81%) | 7 (54%, 70%) | 18 (38%, 49%) | 0.016 |
Distal | 5 (16%, 19%) | 3 (23%, 30%) | 19 (40%, 51%) | Â |
Differentiation | Â | Â | Â | Â |
Moderate | 10 (31%, 38%) | 9 (69%, 90%) | 30 (64%, 81%) | 0.012 |
Moderate, mucinous | 7 (22%, 27%) | 1 (8%, 10%) | 5 (11%, 14%) | 0.197 |
Poor | 4 (13%, 15%) | 0 (0%) | 2 (4%, 5%) | 0.209 |
Well | 4 (13%, 15%) | 0 (0%) | 0 (0%) | 0.075 |
Gene panel CIMP status | Â | Â | Â | Â |
CIMP-H | 27 (84%) | 1 (8%) | 7 (15%) | < 0.001 |
CIMP-L | 4 (13%) | 1 (8%) | 7 (15%) | Â |
CIMP-N | 1 (3%) | 11 (85%) | 30 (64%) | < 0.001 |
Age (SD) | 73.6 (7.7) | 69.2 (11) | 69 (12.3) | 0.07 |