Table 3 Attributes of commonly reported prognostic factors
Prognostic factor | Number of studies | Total # of pts., N | Univariate analysis Significant/ tested/% significant | Multivariable analysis Significant/ tested/% significant | Hematological malignancies tested |
|---|---|---|---|---|---|
Older age | 22 | 10,027 | 6/20 (30%) | 5/16 (31%) | • Acute leukemia • All hematological malignancies • AML • Cord HSCT • HSCT |
Mechanical ventilation | 18 | 9702 | 13/17 (76%) | 12/14 (86%) | • Acute leukemia • All hematological malignancies Cord HSCT • HSCT • Lymphoma |
Vasopressors use | 15 | 1300 | 12/15 (80%) | 8/9 (89%) | • Acute leukemia • All hematological malignancies • AML • Cord HSCT • HSCT |
Renal replacement therapy | 7 | 633 | 3/7 (43%) | 3/4 (75%) | • All hematological malignancies • AML • HSCT |
Transfusions | 4 | 490 | 2/4 (50%) | 2/4 (50%) | • Acute leukemia • All hematological malignancies • HSCT |
Admission to intensive care unit | 1 | 85 | 1/1 (100%) | 1/1 (100%) | • HSCT |
Artificial feeding | 1 | 290 | 1/1 (100%) | 1/1 (100%) | • All hematological malignancies |
Opiate analgesia | 1 | 290 | 1/1 (100%) | 1/1 (100%) | • All hematological malignancies |
Sepsis/infection | 17 | 9170 | 9/16 (56%) | 8/14 (57%) | • Acute leukemia • All hematological malignancies • AML • HSCT • Lymphoma |
Hemodynamic instability | 9 | 8095 | 6/8 (75%) | 5/8 (62%) | • All hematological malignancies • AML • Cord HSCT • HSCT • Lymphoma |
Multi organ failure | 9 | 657 | 6/8 (75%) | 5/6 (83%) | • All hematological malignancies • HSCT |
Respiratory distress/failure | 13 | 8715 | 5/12 (42%) | 5/10 (50%) | • Acute leukemia • All hematological malignancies AML • Cord HSCT • HSCT • Lymphoma |
Cardiovascular function | 5 | 711 | 3/5 (60%) | 3/5 (60%) | • All hematological malignancies • HSCT • Acute leukemia |
Decreased level of consciousness | 10 | 1169 | 3/9 (33%) | 3/8 (37%) | • Acute leukemia • All hematological malignancies • HSCT • Lymphoma |
Renal dysfunction | 8 | 8205 | 2/6 (33%) | 2/3 (66%) | • Acute leukemia • All hematological malignancies • AML • Cord HSCT • HSCT • Lymphoma |
Fungal infection | 4 | 382 | 2/4 (50%) | 2/4 (50%) | • Acute leukemia • All hematological malignancies • HSCT |
Liver dysfunction | 7 | 478 | 3/7 (43%) | 3/4 (75%) | • Acute leukemia • AML • Cord HSCT • All hematological malignancies • HSCT |
Pneumonia | 4 | 173 | 2/4 (50%) | 0/1 (0%) | • All hematological malignancies • Cord HSCT • HSCT |
CMV reactivation | 1 | 86 | 1/1 100% | 0/1 0% | • All hematological malignancies |
Performance status | 4 | 775 | 1/4 (25%) | 1/4 (25%) | • Acute leukemia • All hematological malignancies |
Disease characteristics | |||||
Acute leukemia | 11 | 9352 | 2/10 (20%) | 4/10 (40%) | • All hematological malignancies • Cord HSCT • HSCT |
Relapse or advanced disease | 10 | 862 | 4/10 (40%) | 4/8 (50%) | • Acute leukemia • All hematological malignancies • AML • Cord HSCT • HSCT |
HSCT | 9 | 8617 | 1/8 (12%) | 1/7 (14%) | • All hematological malignancies • HSCT |
Laboratory values | |||||
Liver enzymes | 11 | 823 | 7/11 (64%) | 5/6 (83%) | • Acute leukemia • All hematological malignancies • AML • HSCT |
Urea or creatinine | 11 | 8294 | 5/10 (50%) | 3/7 (43%) | • Acute leukemia • All hematological malignancies • AML • Cord HSCT • HSCT |
Neutropenia or leukopenia | 15 | 9244 | 5/14 (36%) | 5/12 (42%) | • All hematological malignancies • AML • HSCT |
Thrombocytopenia | 10 | 8614 | 5/9 (55%) | 4/6 (67%) | • All hematological malignancies • AML • Cord HSCT • HSCT |
Coagulopathy | 8 | 512 | 4/7 (57%) | 3/4 (75%) | • Acute leukemia • All hematological malignancies • AML • HSCT • Lymphoma |
Anemia | 4 | 477 | 4/4 (100%) | 4/4 (100%) | • All hematological malignancies • HSCT |
Blood pH | 3 | 7960 | 2/3 (66%) | 2/2 (100%) | • All hematological malignancies |
Calcium | 2 | 338 | 2/2 (100%) | 2/2 (100%) | • All hematological malignancies • HSCT |
CRP | 3 | 368 | 2/3 (66%) | 2/2 (100%) | • All hematological malignancies • AML • HSCT |
Hematocrit | 4 | 7859 | 1/3 (33%) | 2/4 (50%) | • All hematological malignancies |
Hypoalbuminemia | 5 | 570 | 2/5 (40%) | 2/4 (50%) | • All hematological malignancies • AML • HSCT |
Lactate | 2 | 133 | 2/2 (100%) | 2/2 (100%) | • HSCT |
LDH | 2 | 7737 | 2/2 (100%) | 2/2 (100%) | • All hematological malignancies • HSCT |
Sodium | 2 | 338 | ½ (50%) | 2/2 (100%) | • All hematological malignancies • HSCT |
Bicarbonate | 1 | 48 | 1/1 (100%) | 1/1 (100%) | • HSCT |
Pro-calcitonin | 1 | 48 | 1/1 (100%) | 1/1 (100%) | • HSCT |
Uric acid | 1 | 48 | 1/1 (100%) | 1/1 (100%) | • HSCT |