Table 3 Comparison of ROC areas among the combination of 3 biomarkers

1

ROC area

0.619 ± 0.014

0.623 ± 0.014

0.623 ± 0.015

0.625 ± 0.015

(95% CI)

(0.591–0.646)

(0.595–0.650)

(0.594–0.653)

(0.596–0.655)

Sensitivity

99.4

100

99.8

99.8

Specificity

8.7

4.4

4.6

4.6

3

ROC area

0.620 ± 0.014

0.624 ± 0.014

0.630 ± 0.015

0.632 ± 0.015

(95% CI)

(0.591–0.648)

(0.596–0.652)

(0.600–0.660)

(0.602–0.662)

Sensitivity

99.0

99.2

98.6

98.6

Specificity

11.9

11.9

12.7

12.7

5

ROC area

0.619 ± 0.015

0.624 ± 0.014

0.633 ± 0.016

0.635 ± 0.016

(95% CI)

(0.591–0.648)

(0.595–0.652)

(0.603–0.665)

(0.605–0.666)

Sensitivity

98.4

98.4

97.8

97.8

Specificity

16.9

16.9

17.9

17.7

7

ROC area

0.621 ± 0.015

0.625 ± 0.015

0.634 ± 0.016

0.637 ± 0.016

(95% CI)

(0.593–0.650)

(0.597–0.654)

(0.604–0.664)

(0.606–0.667)

Sensitivity

97.4

97.4

96.6

96.6

Specificity

19.1

19.1

20.1

20.1

10

ROC area

0.622 ± 0.015

0.626 ± 0.015

0.636 ± 0.016

0.638 ± 0.016

(95% CI)

(0.593–0.651)

(0.597–0.655)

(0.605–0.667)

(0.607–0.669)

Sensitivity

97.2

97.2

96.4

96.4

Specificity

21.1

21.1

22.1

22.1