From: BK-UM in patients with recurrent ovarian cancer or peritoneal cancer: a first-in-human phase-I study
 | Level 1 | Level 2 | Level 3 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Patient no. | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 |
Appetite loss | 2 | 2 | Â | Â | Â | Â | Â | Â | Â | Â | Â |
General fatigue | Â | Â | Â | Â | Â | Â | Â | Â | 2 | Â | Â |
Nausea | Â | 2 | Â | Â | Â | Â | Â | Â | 2 | Â | Â |
Vomiting | Â | 2 | Â | Â | Â | Â | Â | Â | 2 | Â | Â |
Ileus | Â | 2 | Â | Â | Â | 3 | Â | Â | Â | Â | Â |
Constipation | 2 | Â | Â | Â | Â | 2 | Â | Â | 2 | Â | Â |
Diarrhea | Â | Â | Â | Â | Â | 2 | Â | Â | Â | Â | Â |
Abdominal pain | Â | 2 | Â | Â | Â | 2 | Â | Â | Â | Â | Â |
Abdominal fullness | 2 | Â | Â | Â | Â | 3 | Â | Â | Â | Â | Â |
Intraabdominal bleeding | Â | Â | Â | Â | Â | Â | Â | Â | Â | 2 | Â |
Lumbago | Â | Â | Â | Â | Â | 2 | Â | Â | Â | Â | Â |
Headache | Â | Â | Â | Â | Â | 2 | Â | Â | Â | Â | Â |
Fever | Â | Â | Â | Â | Â | 2c | 2c | Â | Â | Â | Â |
Dyspnea | Â | Â | Â | Â | Â | Â | Â | Â | 2 | Â | Â |
Hematomaa | Â | Â | Â | Â | Â | Â | 2 | Â | Â | Â | Â |
Erythema | Â | Â | Â | Â | Â | Â | Â | Â | 2 | Â | Â |
Anemia | 2 | Â | Â | 2 | 2 | 3 | 2 | Â | Â | Â | Â |
Elevation of ALT | Â | Â | Â | Â | Â | Â | 2 | Â | Â | Â | Â |
Elevation of CRP | Â | Â | 2 | Â | Â | Â | 2c | 2c | Â | Â | Â |
Hypoalbuminemia | 2 | Â | 2 | Â | Â | Â | Â | Â | Â | Â | Â |
Hypotensionb | Â | Â | Â | Â | Â | Â | Â | 3c | Â | Â | 3c |