Fig. 4

Endothelial-specific and ubiquitous Dll4 loss-of-function inhibits the Apc ^Min/+ small and large intestinal tumor development. a-b Graphic bars represent the average ± SEM tumor number (a) and volume (b) (mm³) in the small and large intestine of induced Apc ^Min/+ endoDll4 ^-/- and Apc ^Min/+ ubiqDll4 ^-/- mice versus their controls (Apc ^Min/+ endoDll4 ^+/+ and Apc ^Min/+ ubiqDll4 ^+/+) at 18 weeks of age. c Graphic bars represent the average ± SEM tumor burden (mm³) in the whole intestine of the animals described above. One experiment with n = 12 per group. *P < 0.05; **P < 0.01. d-e Photographs of the small and large intestines (tumors indicated by arrows) collected from the endothelial-specific mutants (d) and from the ubiquitous mutants (e) versus the respective controls