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Fig. 1 | BMC Cancer

Fig. 1

From: Delta-like 4/Notch signaling promotes Apc Min/+ tumor initiation through angiogenic and non-angiogenic related mechanisms

Fig. 1

Notch pathway expression pattern in the small intestine and in Apc Min/+ small intestinal adenomas. a-g Immunohistochemical analysis of Notch ligands and receptors expression (indicated by a red arrow) in three series of sequential sections of the normal small intestine of C57Bl/6 mice, and in Apc Min/+ small intestinal adenomas (n = 2 per group, and 2 sections per slide). Control staining was performed with the specific species IgG. Notch ligands (a-c) and receptors (d-f) expression in the small intestinal crypts (a, d), villi (b, e) and adenomas (c, f). Scale bar = 20 μm. Black arrow indicates a Paneth cell (a). Red arrow points to an enterocyte (b); Yellow arrow indicates a goblet cell (b); Orange arrow in (c) indicates the tumor epithelium; Green arrow points out a neutrophil (c). LP lamina propria, S stroma. g Graphic bars represent the average staining score ± SEM for each protein in the normal small intestine (SI) and adenomas of the same region. *P < 0.05; **P < 0.01

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