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Table 5 Expression of CD34, smooth muscle actin and glutamine synthetase in patients with chemotherapy-induced SOS

From: Chemotherapy-induced Sinusoidal Injury (CSI) score: a novel histologic assessment of chemotherapy-related hepatic sinusoidal injury in patients with colorectal liver metastasis

Case

 

Histologic Grade

Trichrome

Immunohistochemistry Grade

  

No.

Agea

SI

NRH

VO

SOS-I

 

CD34

SMA

GS

CSI score

Chemotherapy (cycle #)

1

70–74

3

1

0

4

1

3

3

0

6

capecitabine and oxaliplatin (2)

2

65–69

3

1

0

4

1

3

3

0

6

FOLFOX (4)

3

65–69

3

1

0

4

0

3

3

0

6

capecitabin, oxaliplatin (2) and cetuximab

4

55–59

3

1

0

4

0

3

1

3

7

FOLFOX (*) and bevacizumab

5

65–69

3

1

0

4

1

3

2

3

8

FOLFOX (*)

6

60–64

3

1

0

4

1

3

3

3

9

FOLFOX (6)

7

70–74

3

1

0

4

0

2

3

0

5

FOLFOX and bevacizumab (6)

8

50–54

2

1

0

3

1

0

0

0

0

FOLFOX (6)

9

70–74

2

1

0

3

1

2

0

0

2

FOLFOX (*)

10

65–69

2

1

0

3

0

2

3

0

5

FOLFOX (*) and bevacizumab

11

65–69

3

0

0

3

1

3

3

2

8

FOLFOX (4)

12

55–59

3

0

0

3

1

3

3

1

7

FOLFOX (3) and bevacizumab

13

75–79

2

1

0

3

0

3

0

0

3

FOLFOX (*)

14

70–74

0

1

2

3

1

0

3

3

6

FOLFOX (12)

15

30–34

1

1

0

2

0

2

3

0

5

FOLFOX (8), converted to FOLFIRI and bevacizumab

16

50–54

2

0

0

2

1

2

3

0

5

FOLFOX (6) and cetuximab

17

50–54

2

0

0

2

0

0

0

0

0

FOLFOX (8), converted to FOLFIRI, bevacizumab and cetuximab

18

55–59

2

0

0

2

0

0

3

0

3

FOLFOX (4) and bevacizumab

19

45–49

2

0

0

2

1

1

3

3

7

FOLFOX (5) and cetuximab converted to FOLFIRI

20

55–59

1

1

0

2

0

1

0

0

1

FOLFOX (6)

21

55–59

2

0

0

2

1

2

3

0

5

FOLFOX (*), converted to FOLFIRI, avastin and cetuximab

22

50–54

1

1

0

2

1

2

0

0

2

FOLFIRI and cetuximab

23

55–59

1

0

0

1

1

0

2

0

2

none

24

60–64

1

0

0

1

0

1

0

0

1

none

25

50–54

0

1

0

1

1

2

0

0

2

none

26

70–74

1

0

0

1

0

0

0

0

0

none

27

60–64

1

0

0

1

1

0

3

0

3

none

28

55–59

1

0

0

1

0

0

0

0

0

none

29

85–89

0

0

0

0

0

0

0

0

0

none

30

75–79

0

0

0

0

0

0

0

0

0

none

  1. aAges were replaced by age ranges to maintain partient confidentiality
  2. SOS sinusoidal obstruction syndrome, SI sinusoidal injury, NRH nodular regenerative hyperplasia, VO venous obstruction, SOS-I SOS index, SMA smooth muscle actin, GS glutamine synthetase, CSI score chemotherapy-induced sinusoidal injury score, OX oxaliplatin, *unknown cycle