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Table 1 Association between the tumor LINE-1 methylation levels and clinicopathological characteristics of the advanced-stage CRC patients

From: Prognostic and predictive significance of long interspersed nucleotide element-1 methylation in advanced-stage colorectal cancer

 

n

LINE-1 methylation

p-value

Gender

 Male

26

46.8

(39.8–53.2)

0.738

 Female

15

48.5

(43.6–53.0)

 

Age (years)

 65≥

20

47.4

(43.1–51.7)

0.806

 >65

21

47.4

(41.4–52.6)

 

Sites of primary tumors

 Colon

25

47.2

(42.2–51.7)

0.517

 Rectum

16

47.7

(43.0–54.2)

 

Tumor histological types

 Well-differentiated

4

47.6

(45.6–52.9)

0.941

 Moderately-differentiated

34

47.5

(42.5–53.2)

 

 Poorly-differentiated

3

46.7

(41.5–52.9)

 

Status

 Advanced (stage IV)

18

45

(42.1–48.9)

0.113

 Recurrence

23

49.3

(43.3–54.4)

 

Distant metastasis

 One organ

29

48.4

(43.8–54.0)

0.185

 Multiple organs

12

45

(40.7–51.4)

 

Previous treatment with 5-FU

 Yes

22

48.8

(42.5–53.2)

0.429

 No

19

45.8

(42.6–51.7)

 

Number of previous regimens

 0

30

46.8

(43.5–52.3)

0.612

 1

11

49.1

(40.1–55.8)

 
  1. LINE-1 methylation levels are shown as the median value (25th–75th percentile). Histological type of the primary tumor was classified into well-, moderately- and poorly-differentiated adenocarcinoma according to their grading. 5-FU, 5-fluorouracil; LINE-1, long interspersed nucleotide element-1; n, number of patients
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BMC Cancer

ISSN: 1471-2407

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