Patient characteristics | Group | N | (%) | |
---|---|---|---|---|
Demographics | Age group (years) | <45 | 141 | (13) |
45-55 | 242 | (23) | ||
56-69 | 393 | (37) | ||
≥70 | 266 | (25) | ||
Surgery type | Primary tumour | WLE or partial mastectomy | 608 | (57) |
Total mastectomy | 452 | (42) | ||
Lymph node | Sentinel node biopsy only | 703 | (66) | |
Axillary lymph node dissection | 255 | (24) | ||
Nodal status | Sentinel lymph node | Involved | 269 | (25) |
Not involved | 590 | (55) | ||
Axillary lymph nodes involved | No | 625 | (59) | |
1-3 | 240 | (23) | ||
≥4 | 108 | (11) | ||
Extranodal spread | Present | 140 | (13) | |
Histopathology | Cell type | Invasive ductal carcinoma | 818 | (77) |
Invasive lobular carcinoma | 135 | (13) | ||
Tubular carcinoma | 27 | (3) | ||
Mucinous carcinoma | 12 | (1) | ||
Medullary carcinoma | 8 | (0.8) | ||
Mixed type | 8 | (0.8) | ||
Basal type | 7 | (0.7) | ||
Metaplastic carcinoma | 7 | (0.7) | ||
Other malignant tumour | 42 | (4) | ||
Multifocal | Multifocal | 83 | (9) | |
Satellite lesions | 66 | (6) | ||
Primary tumour size (cm) | ≤0.5 (T1a) | 42 | (4) | |
0.6-1.0 (T1b) | 149 | (14) | ||
1.1-2.0 (T1c) | 423 | (40) | ||
2.1-5.0 (T2) | 347 | (33) | ||
>5.0 (T3) | 79 | (7) | ||
Histological grade | Grade 1 | 172 | (12) | |
Grade 2 | 445 | (42) | ||
Grade 3 | 418 | (39) | ||
Lymphovascular invasion | Present | 356 | (33) | |
Absent | 308 | (29) | ||
Perineural invasion | Present | 40 | (4) | |
Absent | 111 | (10) | ||
Oestrogen receptor (ER) status | Positive | 927 | (87) | |
Negative | 135 | (13) | ||
Progesterone receptor (PR) status | Positive | 843 | (79) | |
Negative | 210 | (20) | ||
HER2 statusa | Positive | 128 | (12) | |
Negative | 654 | (61) | ||
Basal Type | Yes | 31 | (3) | |
Cytokeratin 5/6 | Positive | 59 | (6) | |
Ki-67 (%) | <5% | 94 | (9) | |
5-9% | 130 | (12) | ||
10-29% | 231 | (22) | ||
≥30% | 153 | (14) | ||
Associated lesions | Second primary | Present | 31 | (3) |
Ductal carcinoma in situ | High Grade | 335 | (32) | |
Intermediate Grade | 196 | (18) | ||
Low grade | 43 | (4) | ||
Extensive | 346 | (33) | ||
Focal | 318 | (30) | ||
Lobular carcinoma in situ | Focal | 89 | (8) | |
Extensive | 60 | (6) | ||
Other benign lesion(s) | Present | 95 | (9) |