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Table 4 Recurrence and breast cancer mortality in relation to BRCA status

From: Tumor characteristics and prognosis in familial breast cancer

 

Person-yearsa

No. of events

Rate x1000 person-years (95% CI)b

DFS

 BRCA-positive

257

9

35 (16–66)

 BRCA-wild type

702

22

31 (20–47)

 Sporadic

12721

522

48 (45–53)

OS

 BRCA-positive

312

10

32 (15–59)

 BRCA-wild type

814

18

22 (13–35)

 Sporadic

14943

598

40 (37–43)

  1. The 21 patients carrying variants of unknown significance were excluded from the analysis
  2. CI confidence interval, DFS disease-free survival, OS overall survival
  3. aRates were calculated from the reference date (i.e. date of diagnosis)
  4. bConfidence interval by Haenszel et al. JNCI 1962