Association of nutritional status-related indices and chemotherapy-induced adverse events in gastric cancer patients

Table 4 Multivariable logistic regression analysis of risk factors for hematological adverse events

Variables		Grade 0–2 (N = 196)	Grade 3–4 (N = 38)	Univariate		Multivariate ^a)
Variables		Grade 0–2 (N = 196)	Grade 3–4 (N = 38)	OR (95% CI)	p	OR (95% CI)	p
Age (y)				0.99 (0.96–1.02)	0.472
Sex	Female	66 (75.9%)	21 (24.1%)	2.43 (1.20–4.92)	0.013	2.39 (1.15–4.96)	0.020
Sex	Male	130 (88.4%)	17 (11.6%)	1.00	0.013	1.00	0.020
Operation type	Total	72 (77.4%)	21 (22.6%)	2.13 (1.05–4.29)	0.035	1.79 (0.86–3.74)	0.119
Operation type	Distal	124 (87.9%)	17 (12.1%)	1.00	0.035	1.00	0.119
Creatinine clearance (mL/min) ^b)	≥60	165 (83.8%)	32 (16.2%)	1.00	0.997
Creatinine clearance (mL/min) ^b)	<60	31 (83.8%)	6 (16.2%)	0.99 (0.39–2.59)	0.997
Albumin (g/dL)	<3.5	24 (70.6%)	10 (29.4%)	2.56 (1.11–5.92)	0.028	2.45 (1.02–5.89)	0.045
Albumin (g/dL)	≥3.5	172 (86.0%)	28 (14.0%)	1.00	0.028	1.00	0.045
BMI (kg/m²)				0.83 (0.72–0.95)	0.007	0.86 (0.74–0.99)	0.035
PG-SGA category	A	78 (81.3%)	18 (18.8%)	1.00	0.078
PG-SGA category	B	118 (85.5%)	20 (14.5%)	0.44 (0.17–1.09)	0.078
PG-SGA score				0.88 (0.76–1.01)	0.083
Weight loss (%)				0.97 (0.88–1.07)	0.558
NRI				0.96 (0.89–1.02)	0.163

^a)Covariates used in multivariate analyses included sex, operation type, albumin, and BMI; ^b)Creatinine clearance was calculated using the Cockroft–Gault formula; BMI Body Mass Index, PG-SGA Patient-Generated Subjective Global Assessment, NRI Nutritional Risk Index

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