Table 2 Univariate analysis of pre-operative, tumoral post-operative, therapeutic post operative and lymphopenia parameters for association with Overall Survival (N = 390)

Pre-operative parameters

  ≤ 65

174

130

1

  > 65

216

179

1.405

[1.120; 1.764]

0.0034

 Male

222

169

1

 Female

168

140

1.224

[0.978; 1.533]

0.0769

 No

252

199

1

 Yes

73

61

1.188

[0.891; 1.584]

0.2416

Albuminemia

191

154

0.973

[0.953; 0.993]

0.0089

Tumor Size in cm

301

233

1.011

[0.931; 1.099]

0.7899

Post-operative tumoral parameters

 0-1-2

39

27

1

 3–4

336

270

1.331

[0.895; 1.980]

0.1575

 0

119

89

 1

269

218

1.148

[0.897; 1.470]

0.2740

  < 0.2

279

205

  ≥ 0.2

104

96

1.759

[1.373; 2.252]

<0.0001

Positive lymp nodes ratio (N+/Total number of lymph nodes)

380

300

3.308

[1.962; 5.577]

<0.0001

 Poorly differentiated

85

67

1

 Moderately differentiated

158

127

0.797

[0.592; 1.072]

 Well differentiated

88

64

0.672

[0.476; 0.947]

0.0735

 No

242

179

1

 Yes

119

102

1.437

[1.125; 1.836]

0.0037

 No

230

174

1

 Yes

134

110

1.199

[0.944; 1.524]

0.1374

 No

138

103

1

 Yes

227

183

1.172

[0.920; 1.493]

0.1989

Therapeutic post-operative parameter

 No

85

73

1

 Yes

251

194

0.505

[0.385; 0.663]

<0.0001

Lymphopenia parameters

Pre-operative lymphocyte count

390

309

0.692

[0.546; 0.877]

0.0023

Post-operative lymphocyte count

301

225

0.674

[0.508; 0.895]

0.0065

  ≤ 1000

110

98

1

  > 1000

280

211

0.693

[0.545; 0.881]

0.0028

  ≤ 1000

65

56

1

  > 1000

236

169

0.485

[0.356; 0.660]

<0.0001

  > 1000/>1000

182

123

1

  ≤ 1000/>1000

54

46

1.486

[1.058; 2.088]

  > 1000/≤1000

37

30

2.213

[1.476; 3.317]

  ≤ 1000/≤1000

28

26

2.340

[1.524; 3.593]

<0.0001