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Table 1 Baseline characteristics of the overall population and according to the two cohort sets

From: Additive value of pre-operative and one-month post-operative lymphocyte count for death-risk stratification in patients with resectable pancreatic cancer: a multicentric study

 

Patients Characteristics

Overall population (N =390)

Cohort set 1 (N =192)

Cohort set 2 (N =198)

P

 

N

 

N

 

N

  

Pre-operative parameters

Age at surgery — years

390

 

192

 

198

  

   ≤ 65

 

174 (45 %)

 

87 (45 %)

 

87 (44 %)

 

   > 65

 

216 (55 %)

 

105 (55 %)

 

111 (56 %)

0.8387

Patient male sex — no. (%)

390

222 (57 %)

192

103 (54 %)

198

119 (60 %)

0.2201

Diabetes — no. (%)

325

 

186

 

139

  

 No

 

252 (78 %)

 

143 (77 %)

 

109 (78 %)

 

 Yes

 

73 (22 %)

 

43 (23 %)

 

30 (22 %)

0.7891

Albuminemia g/L

191

36.4 ± 7.7

70

32.6 ± 6.4

121

38.6 ± 7.4

<0.0001

Tumor Size in cm

301

3.8 ± 1.6

164

3.6 ± 1.5

137

4.0 ± 1.6

0.0095

Tumoral post-operative parameters

pT Local invasion — no. (%)

375

 

184

 

193

  

 0-1-2

 

39 (10 %)

 

28 (15 %)

 

11 (6 %)

 

 3–4

 

336 (90 %)

 

154 (85 %)

 

182 (94 %)

0.0022

N status

388

 

190

 

198

  

 0

 

119 (31 %)

 

68 (36 %)

 

51 (26 %)

 

 1

 

269 (69 %)

 

122 (64 %)

 

147 (74 %)

0.0365

Positive lymph nodes ratio

380

0.15 ± 0.19

182

0.20 ± 0.23

198

0.12 ± 0.14

<0.0001

Lymph Nodes ratio

  < 0.2

380

279 (73 %)

 

117 (64 %)

 

162 (81 %)

 

  ≥ 0.2

 

104 (27 %)

 

67 (36 %)

 

37 (19 %)

<0.0001

Histological Grade

331

 

160

 

171

  

 Poorly differentiated

 

85 (26 %)

 

23 (14 %)

 

62 (36 %)

 

 Moderately differentiated

 

158 (48 %)

 

76 (48 %)

 

82 (48 %)

 

 Well differentiated

 

88 (26 %)

 

61 (38 %)

 

27 (16 %)

<0.0001

Vascular invasion

361

 

186

 

175

  

 No

 

242 (67 %)

 

115 (62 %)

 

127 (73 %)

 

 Yes

 

119 (33 %)

 

71 (38 %)

 

48 (27 %)

0.0335

Lymphatic invasion

364

 

189

 

175

  

 No

 

230 (63 %)

 

107 (57 %)

 

123 (70 %)

 

 Yes

 

134 (37 %)

 

82 (43 %)

 

52 (30 %)

0.0089

Perineural invasion

365

 

191

 

174

  

 No

 

138 (38 %)

 

57 (30 %)

 

81 (47 %)

 

 Yes

 

227 (62 %)

 

134 (70 %)

 

93 (53 %)

0.0012

Therapeutic post-operative parameter

Adjuvant Chemotherapy

336

251 (75 %)

183

118 (64 %)

153

133 (87 %)

<0.0001

Lymphopenia parameters

Pre-operative lymphocyte counta

390

1458.9 (150–8350)

194

1492.1 (170–3052)

199

1426 (150–8350)

0.3362

Post-operative lymphocyte counta

299

1410 (200–32000)

127

1400 (251–3620)

172

1430 (200–32000)

0.2657

Follow-up parameters

Death events

393

309 (79 %)

192

157 (82 %)

198

152 (77 %)

0.2233

Median F-up time in months 95 % CIb

 

66.6 (60.8–78.7)

 

66.6 (58.0–84.0)

 

67.2 (56.2–79.0)

 
  1. Abbreviations: pT histologic tumoral invasion, Nstatus lymph node status, F-up follow-up, lymph node ratio (Number of positive lymph nodes/Total number of lymph nodes)
  2. amedian (min-max) were reported for lymphocyte count due to their skewed distribution
  3. bCI denotes confidence interval
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BMC Cancer

ISSN: 1471-2407

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