Influence of dosing times on cisplatin-induced peripheral neuropathy in rats

BMC Cancer

Table 1 Time courses of paw withdrawal thresholds and withdrawal latency during the weekly administration of CDDP to rats

Behavioral test	Groups	Time before/after the first administration (days)
Behavioral test	Groups	−1	6	13	20	27
von-Frey test	Control	51.5 ± 5.6 g	51.5 ± 5.6 g	47.3 ± 6.2 g	45.9 ± 7.0 g	51.5 ± 5.6 g
von-Frey test	CDDP	55.8 ± 4.3 g	15.9 ± 2.4 g**	40.3 ± 7.6 g	56.5 ± 8.3 g	70.8 ± 9.5 g
Hot-plate test	Control	15.9 ± 1.5 sec	14.5 ± 0.4 sec	-	-	14.4 ± 1.4 sec
Hot-plate test	CDDP	14.4 ± 1.8 sec	9.7 ± 0.9 sec**	-	-	37.1 ± 7.3 sec*

Each data represent the mean with S.E.M. in the von-Frey test (n = 8) and in the hot-plate test (n = 4), *: P < 0.05, and **: P < 0.01 using the Student’s t-test

ISSN: 1471-2407