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Table 2 Radiotherapy dose escalation levels

From: A phase-I trial of pre‐operative, margin intensive, stereotactic body radiation therapy for pancreatic cancer: the ‘SPARC’ trial protocol

Radiotherapy dose level

Tumour (PTV)

Area at risk of R1 (PTV_R)

Dose/# [Gy]

Total dose [Gy]

*BED [Gy10]

EQD2 [Gy]

Dose/# [Gy]

Total dose [Gy]

*BED [Gy10]

EQD2 [Gy]

Level −1

6

30

50

40

8

40

72

60

Level 1

6

30

50

40

9

45

88

71.5

Level 2

6.5

32.5

56

45

9.5

47.5

92

77.2

Level 3

7

35

62

50

10

50

100

83.3

  1. *BED [Gy 10 ] biologically effective dose for acute reacting tissues (α/β = 10), EQD 2 equivalent dose in 2-Gy fractions