From: Changes in the in vitro activity of platinum drugs when administered in two aliquots
 | Cytotoxic effect | Cellular accumulation | DNAbinding | Proteomicsa | ||||||
---|---|---|---|---|---|---|---|---|---|---|
 | Fresh | Aged | Fresh | Aged | Fresh | Aged | Fresh | Aged | ||
CS + CS | ||||||||||
2 h | Antagonistic | Synergistic | Unchanged | Increased | Increased | Greater increase | COF2 MARE1 NPM ANXA1 RSSA ACTB CALU HNRPF ATPA HNRPK CH60 TCPQ GLU2B HSP74 HNRPC CALR VIME | (D,R), (D,R), (D,R), (D,R), (U,R), (U,R), (U,OR), (D,R), (U,OR), (U,OR), (U,OR), (D,OR), (U,OR), (D,OR), (U,R), (U,R), (U,OR). | COX5A COF2 1433γ MARE1 NPM ANXA1 HNRPF ENOA ATPA PDIA3 TCPQ GRP75 HNRPC CALR | (D,OR), (D,OR), (D,OR), (D,OR), (D,OR), (D,OR), (D,OR), (D,R), (U,OR), (D,R), (D,R), (D,R), (U,R), (U,OR). |