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Fig. 6 | BMC Cancer

Fig. 6

From: Inhibition of nuclear factor-kappa B enhances the tumor growth of ovarian cancer cell line derived from a low-grade papillary serous carcinoma in p53-independent pathway

Fig. 6

NF-kB induced apoptosis in p53-independent pathway in BALB/athymic nude mice. a Inhibition of NF-kB activity can induce tumor growth in p53-independent pathway in vivo. b Tumor growth following etopic expression of IkBαM in BALB/athymic nude mice in p53-independent pathway. c A model illustrating that inhibition of NF-kB signaling in ovarian tissue results in an increased proliferation rate and the development of ovarian tumors. Furthermore, neither mutations in the KRAS nor decreasing expression of p53 gene can affect the tumor development induced by IkBαM

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BMC Cancer

ISSN: 1471-2407

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