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Fig. 5 | BMC Cancer

Fig. 5

From: Inhibition of nuclear factor-kappa B enhances the tumor growth of ovarian cancer cell line derived from a low-grade papillary serous carcinoma in p53-independent pathway

Fig. 5

Correlation of nuclear localization of p65 NF-kB and clinicopathologic characteristics and a model of the NF-kB role in ovarian cancer. a Representative images showing high and low nuclear expression of p65 in high-grade ovarian cancer tissues. b A model illustrating that NF-kB suppresses tumorigenesis by inhibiting anti-apoptosis through the regulation of MAPK phosphorylation and apoptosis pathway. c Detection of NF-kB1, NF-kB2, MAPK15, KRAS, BRAF, PUMA, MDM2, CIAP by heatmap. d Kaplan-Meier curves showing favorable overall survival rates in patients with low-grade serous ovarian cancer are associated with nuclear expression of p65

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BMC Cancer

ISSN: 1471-2407

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