Fig. 6
From: MK-2206 sensitizes BRCA-deficient epithelial ovarian adenocarcinoma to cisplatin and olaparib
MK-2206 sensitizes BRCA2 mutants to combination therapy with cisplatin and olaparib. PEO1 and PEO4 cells were treated with (a) 0, (b) 3.125, or (c) 6.25 μM MK-2206 in combination with a fixed ratio (1:1) of cisplatin and olaparib. After 72 h, MTS solution was added and absorbance read at 490 nm after 4 h. Data are means ± SD. d CI values were calculated for the drug combinations of cisplatin and olaparib with MK-2206 at each concentration