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Table 3 Mean scores of positivity in nucleus and cytoplasm for the clock proteins

From: Expression of circadian clock genes and proteins in urothelial cancer is related to cancer-associated genes

Protein

Cancer cells

Neighbouring mucosa

Normal mucosa

Nucleus

Cytopl.

Nucleus

Cytopl.

Nucleus

Cytopl.

PER 1

2.17

0

1.71

0

2.00

0

+/− SEM

0.15

0

0.10

0

0

0

PER 3

0.22

0.43

0.67

0.73

0

1.15

+/− SEM

0.08

0.11

0.13

0.15

0

0.13

CRY 1

2.08

1.96

1.84

1.27

1.76

0.62

+/− SEM

0.16

0.11

0.14

0.20

0.13

0.15

CRY 2

0

0.83

2.31

2.75

2.00

2.00

+/− SEM

0

0.13

0.23

0.18

0.26

0.28

BMAL1

1.42

2.40

2.33

2.27

1.16

2.08

+/− SEM

0.20

0.12

0.19

0.20

0.21

0.20

CLOCK

2.04

2.23

2.57

2.52

2.75

2.91

+/− SEM

0.16

0.12

0.13

0.13

0.14

0.09

Casein kinase 1 alpha

 

1.93

2.70

2.78

3.00

2.90

3.00

+/− SEM

0.18

0.10

0.13

0.00

0.11

0.00

Casein kinase 1 alpha 1 L

 

1.96

2.59

2.88

2.96

2.54

2.92

+/−SEM

0.24

0.12

0.08

0.04

0.22

0.08

Casein kinase 1 epsilon

 

2.93

2.07

2.75

1.95

3.00

2.00

+/− SEM

0.05

0.05

0.10

0.09

0

0

  1. +/− SEM: +/− standard error of the arithmetic means