Table 1 Correlations between clinicopathological findings and the expression of Sema4D and PlexinB1
Variables | Sema4D expression | p value | PlexinB1 expression | p value | ||
|---|---|---|---|---|---|---|
Positive | Negative | Positive | Negative | |||
(n = 95) | (n = 131) | (n = 105) | (n = 121) | |||
Age (years) | ||||||
Mean ± SD | 65.2 ± 12.3 | 67.2 ± 10.5 | 0.426 | 67.6 ± 11.0 | 65.8 ± 11.5 | 0.23 |
Gender | ||||||
Male | 51(53.7) | 73(55.7) | 0.76 | 56(53.3) | 68 | 0.666 |
Female | 44(46.3) | 58(44.3) | 49(46.7) | 53 | ||
Stage | ||||||
I | 15(15.8) | 43(32.8) | 0.001 | 16(15.2) | 42 | <0.001 |
II | 21(22.1) | 36(27.5) | 19(18.1) | 38 | ||
III | 59(62.1) | 52(36.7) | 70(66.7) | 41 | ||
Histology | ||||||
Well/mod | 82(86.3) | 120(91.6) | 0.206 | 91 | 111 | 0.217 |
Other | 13(13.7) | 11(8.4) | 14 | 10 | ||
Depth of tumor invasion | ||||||
T1/T2 | 18(18.9) | 50(38.2) | 0.001 | 20 | 48 | 0.006 |
T3/T4 | 77(81.1) | 81(61.8) | 85 | 73 | ||
Lymph node metastasis | ||||||
negative | 37(38.9) | 78(59.5) | 0.001 | 35 | 79 | <0.001 |
positive | 58(61.1) | 53(40.5) | 69 | 42 | ||
Lymphatic invasion | ||||||
Negative | 18(18.9) | 66(50.4) | <0.001 | 21 | 57 | <0.001 |
Positive | 77(81.1) | 65(49.6) | 84 | 64 | ||
Venus invasion | ||||||
Negative | 70(73.7) | 117(89.3) | <0.001 | 76 | 111 | <0.001 |
Positive | 25(26.3) | 14(10.7) | 29 | 10 | ||