Table 4 Overall and subgroups meta-analysis of COX-2 rs5275 polymorphism and HNSCC risk
Overall and subgroups | No. | OR (95 % CI) | Heterogeneity (I2%/p) |
|---|---|---|---|
C vs. T (unadjusted and adjusted) | |||
 Overall (unadjusted) | 4 | 0.92 (0.81–1.04) | 1 %/0.38 |
 Overall (adjusted) | 2 | 1.06 (0.81–1.40) | 0 %/0.33 |
 HWE (Yes–unadjusted) | 3 | 0.94 (0.82–1.06) | 0 %/0.45 |
 HWE (No–unadjusted) | 1 | 0.69 (0.42–1.11) | NA |
 Asians (unadjusted) | 3 | 0.97 (0.87–1.16) | 17 %/0.30 |
 Asians (adjusted) | 2 | 1.06 (0.81–1.40) | 0 %/0.33 |
 Caucasian (unadjusted) | 1 | 0.87 (0.74–1.04) | NA |
 OSCC (unadjusted) | 3 | 0.90 (0.76–1.06) | 0 %/0.52 |
 OSCC (adjusted) | 1 | 0.88 (0.55–1.40) | NA |
 LSCC (unadjusted) | 2 | 0.88 (0.73–1.06) | 47 %/0.17 |
CC vs. TT (unadjusted and adjusted) | |||
 Overall (unadjusted) | 4 | 0.92 (0.67–1.27) | 36 %/0.19 |
 Overall (adjusted) | 4 | 0.92 (0.67–1.27) | 49 %/0.12 |
 HWE (Yes–unadjusted) | 3 | 0.89 (0.64–1.24) | 47 %/0.15 |
 HWE (No–unadjusted) | 1 | 2.59 (0.31–21.82) | NA |
 Asians (unadjusted) | 3 | 1.49 (0.87–2.57) | 0 %/0.86 |
 Asians (adjusted) | 3 | 1.45 (0.81–2.59) | 16 %/0.30 |
 Caucasian (unadjusted) | 1 | 0.71 (0.47–1.07) | NA |
 Caucasian (adjusted) | 1 | 0.75 (0.51–1.10) | NA |
 OSCC (unadjusted) | 3 | 0.92 (0.59–1.43) | 0 %/0.48 |
 OSCC (adjusted) | 3 | 0.89 (0.56–1.40) | 0 %/0.57 |
 LSCC (unadjusted) | 2 | 0.98 (0.35–2.75) | 67 %/0.08 |
 LSCC (adjusted) | 2 | 0.88 (0.34–2.26) | 60 %/0.12 |
CC vs. CT (unadjusted and adjusted) | |||
 Overall (unadjusted) | 4 | 1.02 (0.74–1.41) | 48 %/0.12 |
 Overall (adjusted) | 4 | 0.99 (0.84–1.16) | 0 %/0.60 |
 HWE (Yes–unadjusted) | 3 | 0.96 (0.68–1.33) | 42 %/0.18 |
 HWE (No–unadjusted) | 1 | 5.13 (0.61–42.88) | NA |
 Asians (unadjusted) | 3 | 1.73 (0.99–3.01) | 0 %/0.54 |
 Asians (adjusted) | 3 | 0.93 (0.73–1.19) | 0 %/0.49 |
 Caucasian (unadjusted) | 1 | 0.77 (0.52–1.16) | NA |
 Caucasian (adjusted) | 1 | 1.03 (0.82–1.28) | NA |
 OSCC (unadjusted) | 3 | 0.99 (0.64–1.53) | 44 %/0.17 |
 OSCC (adjusted) | 3 | 1.02 (0.80–1.30) | 28 %/0.25 |
 LSCC (unadjusted) | 2 | 0.87 (0.54–1.40) | 50 %/0.16 |
 LSCC (adjusted) | 2 | 0.92 (0.70–1.21) | 0 %/0.62 |
CC vs. CT + TT (unadjusted) | |||
 Overall | 4 | 0.96 (0.70–1.31) | 43 %/0.15 |
 HWE (Yes) | 3 | 0.91 (0.66–1.25) | 46 %/0.16 |
 HWE (No) | 1 | 3.65 (0.45–29.89) | NA |
 Asians | 3 | 1.58 (0.93–2.71) | 0 %/0.70 |
 Caucasian | 1 | 0.74 (0.50–1.09) | NA |
 OSCC | 3 | 0.94 (0.62–1.43) | 16 %/0.30 |
 LSCC | 2 | 1.02 (0.40–2.60) | 63 %/0.10 |
CC + CT vs. TT (unadjusted and adjusted) | |||
 Overall (unadjusted) | 4 | 0.90 (0.77–1.04) | 0 %/0.41 |
 Overall (adjusted) | 3 | 0.98 (0.84–1.15) | 0 %/0.78 |
 HWE (Yes–unadjusted) | 3 | 0.92 (0.79–1.08) | 0 %/0.74 |
 HWE (No–unadjusted) | 1 | 0.57 (0.30–1.05) | NA |
 Asians (unadjusted) | 3 | 0.91 (0.74–1.12) | 29 %/0.25 |
 Asians (adjusted) | 2 | 1.00 (0.79–1.27) | 0 %/0.49 |
 Caucasian (unadjusted) | 1 | 0.88 (0.70–1.10) | NA |
 Caucasian (adjusted) | 1 | 0.97 (0.78–1.20) | NA |
 OSCC (unadjusted) | 3 | 1.09 (0.55–2.16) | 91 %/<0.05 |
 OSCC (adjusted) | 2 | 1.01 (0.80–1.27) | 2 %/0.31 |
 LSCC (unadjusted) | 2 | 0.87 (0.68–1.10) | 7 %/0.30 |
 LSCC (adjusted) | 2 | 0.89 (0.69–1.15) | 0 %/0.35 |