Table 2 Univariate analyses and adjusted proportional hazard regression analyses of QOL

EORTC-QCQ -C30

Physical functioning

>33.33

87/783

1

1

≤33.33

9/26

3.71

1.87

7.36

3.44

1.72

6.88

Role functioning

>33.33

89/782

1

1

≤33.33

7/27

2.51

1.16

5.41

2.14

0.99

4.65

Emotional functioning

>33.33

92/792

1

1

≤33.33

4/17

2.12

0.78

5.77

2.59

0.94

7.14

Cognitive functioning

>33.33

94/793

1

1

≤33.33

2/16

1.08

0.27

4.37

0.95

0.23

3.90

Social functioning

>33.33

91/786

1

1

≤33.33

5/23

1.99

0.81

4.88

1.56

0.63

3.88

General health status

>33.33

89/770

1

1

≤33.33

7/39

1.62

0.75

3.49

1.35

0.62

2.93

Fatigue

<66.66

83/720

1

1

≥66.66

13/89

1.30

0.72

2.33

1.24

0.69

2.24

Nausea & vomiting

<66.66

94/790

1

1

≥66.66

2/19

0.91

0.23

3.73

0.82

0.20

3.33

Pain

<66.66

87/752

1

1

≥66.66

9/57

1.41

0.71

2.80

1.28

0.61

2.66

Dyspnea

<66.66

53/591

1

1

≥66.66

43/218

2.33

1.56

3.48

1.96

1.30

2.95

Insomnia

<66.66

79/689

1

1

≥66.66

17/120

1.24

0.73

2.09

1.27

0.75

2.16

Appetite loss

<66.66

76/717

1

1

≥66.66

20/92

2.20

1.35

3.61

1.68

1.00

2.82

Constipation

<66.66

87/746

1

1

≥66.66

9/63

1.24

0.63

2.47

1.13

0.57

2.27

Diarrhea

<66.66

88/773

1

1

≥66.66

8/36

2.13

1.03

4.39

2.11

1.01

4.40

Financial difficulties

<66.66

77/686

1

1

≥66.66

19/123

1.39

0.84

2.30

1.14

0.68

1.89

EORTC-QCQ -LC13

Dyspnea

<66.66

77/733

1

1

≥66.66

19/76

2.62

1.59

4.33

2.26

1.36

3.76

Coughing

<66.66

77/726

1

1

≥66.66

19/83

2.35

1.42

3.88

1.92

1.15

3.20

Hemoptysis

<66.66

95/803

1

1

≥66.66

1/6

1.35

0.19

9.67

0.82

0.11

5.94

Sore mouth

<66.66

90/782

1

1

≥66.66

6/26

2.15

0.94

4.91

1.83

0.80

4.19

Dysphagia

<66.66

90/783

1

1

≥66.66

6/26

2.18

0.96

4.99

1.62

0.70

3.74

Peripheral neuropathy

<66.66

84/725

1

1

≥66.66

12/84

1.28

0.70

2.35

1.29

0.70

2.37

Alopecia

<66.66

89/756

1

1

≥66.66

7/52

1.17

0.54

2.53

1.26

0.58

2.74

Pain in chest

<66.66

80/727

1

1

≥66.66

16/82

1.85

1.08

3.16

1.70

0.98

2.95

Pain in arm or shoulder

<66.66

82/699

1

1

≥66.66

14/110

1.09

0.62

1.93

1.22

0.69

2.15

Pain in other body parts

<66.66

83/726

1

1

≥66.66

12/82

1.32

0.72

2.43

1.44

0.78

2.65