From: Better survival in right-sided versus left-sided stage I - III colon cancer patients
Cox regression for overall survival | Cox regression for cancer-specific survival | ||||||||
---|---|---|---|---|---|---|---|---|---|
Unadjusteda | Adjustedb | Unadjusteda | Adjustedb | ||||||
HR (95 % CI) | p c | HR (95 % CI) | p c | HR (95 % CI) | p c | HR (95 % CI) | p c | ||
Cancer side | Left-sided | Reference | <0.001 | Reference | 0.002 | Reference | <0.001 | Reference | 0.156 |
Right-sided | 1.32 (1.29–1.36) | 1.05 (1.02–1.09) | 1.23 (1.19–1.27) | 1.03 (0.99–1.08) | |||||
Tumor stage | Stage I | Reference | <0.001 | Reference | <0.001 | Reference | <0.001 | Reference | <0.001 |
(AJCC 6th ed.) | Stage II | 1.65 (1.59–1.71) | 1.40 (1.35–1.45) | 3.00 (2.81–3.20) | 2.47 (2.31–2.65) | ||||
Stage III | 2.34 (2.26–2.42) | 2.30 (2.22–2.39) | 6.41 (6.02–6.81) | 5.79 (5.42–6.18) | |||||
Number of retrieved | <12 | Reference | <0.001 | Reference | <0.001 | Reference | <0.001 | Reference | <0.001 |
Regional lymph | 12–16 | 0.90 (0.87–0.92) | 0.82 (0.79–0.84) | 0.92 (0.88–0.96) | 0.78 (0.75–0.82) | ||||
Nodes | 17+ | 0.75 (0.73–0.77) | 0.69 (0.67–0.72) | 0.81 (0.78–0.84) | 0.66 (0.64–0.69) | ||||
Grading | G1 | Reference | <0.001 | Reference | <0.001 | Reference | <0.001 | Reference | <0.001 |
G2 | 1.20 (1.14–1.26) | 1.05 (1.00–1.10) | 1.46 (1.36–1.56) | 1.10 (1.03–1.18) | |||||
G3 | 1.76 (1.67–1.85) | 1.28 (1.21–1.35) | 2.60 (2.41–2.81) | 1.51 (1.40–1.64) | |||||
G4 | 2.02 (1.83–2.22) | 1.50 (1.36–1.66) | 2.88 (2.53–3.27) | 1.69 (1.49–1.93) | |||||
Unknown | 0.91 (0.84–1.00) | 1.04 (0.95–1.14) | 1.03 (0.91–1.18) | 1.20 (1.06–1.37) | |||||
Histology | Adenocarcinoma | Reference | <0.001 | Reference | <0.001 | Reference | <0.001 | Reference | <0.001 |
Adenocarcinoma in adenomatous polyp | 0.53 (0.50–0.56) | 0.80 (0.76–0.86) | 0.36 (0.33–0.40) | 0.71 (0.64–0.79) | |||||
Adenocarcinoma in villous adenoma | 0.77 (0.71–0.83) | 0.93 (0.86–1.01) | 0.62 (0.55–0.70) | 0.92 (0.82–1.03) | |||||
Adenocarcinoma in tubulovillous adenoma | 0.63 (0.60–0.67) | 0.84 (0.80–0.89) | 0.44 (0.40–0.47) | 0.73 (0.67–0.79) | |||||
Mucinous carcinoma | 1.12 (1.08–1.17) | 1.03 (0.99–1.07) | 1.14 (1.08–1.20) | 1.05 (0.99–1.10) | |||||
CEA | C0-stage | Reference | <0.001 | Reference | <0.001 | Reference | <0.001 | Reference | <0.001 |
C1-stage | 1.91 (1.84–1.97) | 1.61 (1.56–1.67) | 2.29 (2.19–2.40) | 1.79 (1.71–1.87) | |||||
Unknown/Borderline | 1.42 (1.38–1.46) | 1.37 (1.33–1.41) | 1.49 (1.43–1.55) | 1.48 (1.42–1.54) | |||||
Operation | Segmental resection | Reference | <0.001 | Reference | <0.001 | Reference | <0.001 | Reference | <0.001 |
Hemi/subtotal colectomy | 1.27 (1.24–1.30) | 1.08 (1.05–1.12) | 1.26 (1.22–1.31) | 1.11 (1.06–1.16) | |||||
Other | 1.32 (1.18–1.48) | 1.34 (1.19–1.50) | 1.66 (1.44–1.91) | 1.57 (1.36–1.81) | |||||
Year | 2004 to 2006 | Reference | <0.001 | Reference | 0.258 | Reference | <0.001 | Reference | 0.542 |
2007 to 2009 | 0.93 (0.91–0.96) | 1.02 (0.99–1.05) | 0.93 (0.89–0.96) | 1.02 (0.98–1.06) | |||||
2010 to 2012 | 0.87 (0.83–0.90) | 0.98 (0.94–1.03) | 0.87 (0.83–0.92) | 0.99 (0.94–1.05) | |||||
Age | Up to 49 years | Reference | <0.001 | Reference | <0.001 | Reference | <0.001 | Reference | <0.001 |
50 to 64 years | 1.14 (1.07–1.22) | 1.20 (1.12–1.28) | 0.94 (0.87–1.01) | 1.04 (0.97–1.13) | |||||
65 to 79 years | 2.18 (2.05–2.33) | 2.30 (2.15–2.45) | 1.37 (1.28–1.47) | 1.57 (1.45–1.69) | |||||
80+ years | 5.15 (4.83–5.49) | 5.10 (4.77–5.45) | 2.69 (2.50–2.89) | 2.88 (2.66–3.11) | |||||
Gender | male | Reference | 0.614 | Reference | <0.001 | Reference | 0.001 | Reference | <0.001 |
female | 1.01 (0.98–1.03) | 0.75 (0.73–0.77) | 1.06 (1.02–1.09) | 0.84 (0.81–0.87) | |||||
Ethnicity | Caucasian | Reference | <0.001 | Reference | <0.001 | Reference | <0.001 | Reference | <0.001 |
African-American | 1.03 (0.99–1.07) | 1.17 (1.13–1.22) | 1.19 (1.13–1.25) | 1.24 (1.18–1.30) | |||||
Other/Unknown | 0.70 (0.67–0.74) | 0.77 (0.73–0.81) | 0.81 (0.76–0.87) | 0.83 (0.78–0.89) | |||||
Marital status | Married | Reference | <0.001 | Reference | <0.001 | Reference | <0.001 | Reference | <0.001 |
Single | 1.32 (1.27–1.37) | 1.46 (1.40–1.52) | 1.40 (1.33–1.47) | 1.41 (1.33–1.48) | |||||
Widowed | 2.21 (2.15–2.28) | 1.42 (1.37–1.46) | 1.91 (1.84–1.99) | 1.34 (1.28–1.40) | |||||
Other/Unknown | 1.25 (1.20–1.30) | 1.28 (1.23–1.33) | 1.21 (1.15–1.28) | 1.19 (1.13–1.26) |